CLOVEDIN® - COMPLETELY NATURAL

The essential oils of Cinnamon (Cinnamomum cassia J. Presl.) and Clove (Syzygium aromaticum Merr. et L.M. Perry) have shown synergistic action in our in vitro experiments in combating the proliferation of 18 strains belonging to the Candida genus, including those resistant to major antifungal agents, without altering the vitality of lactobacilli, which are of fundamental importance for the well-being of the vaginal microbiota. The unique formulation of the product allows the two essential oils to bypass the stomach and act in the colon, where alterations of the intestinal microbiota, including the excessive proliferation of Candida spp., commonly occur.

Vitamin A is an essential fat-soluble micronutrient, and its food sources include both preformed vitamin A (mainly retinol and retinyl esters) in animal-derived foods and its precursors in plant-derived foods, such as carotenoids. Its importance lies in its involvement in physiological processes related to vision, as well as in stimulating tissue repair, including epithelial and mucosal tissues, including genital mucosa.

The essential oils in Clovedin® are in a gastro-resistant formulation, which allows them to not be absorbed by the body and to be released directly into the colon. Here, they help promote digestive functions. The balance of digestive functions is directly related to the balance of the intestinal microbiota. The excessive proliferation of opportunistic pathogenic microorganisms, including Candida spp., can lead to imbalances and the development of various pathologies.

Based on scientific evidence, the essential oil of Cinnamon (Cinnamomum cassia J. Presl.) and Clove (Syzygium aromaticum) are considered safe. Both are recognized as GRAS (Generally Recognized As Safe) by the FDA and EFSA.

Clovedin® is GMO-free. It does not contain, derive from, or consist of Genetically Modified Organisms. Clovedin® complies with Regulations EC 1829/2003 and 1830/2003. Specifically, Regulation (EC) No. 1829/2003 of the European Parliament and of the Council of 22 September 2003 on genetically modified food and feed, and Regulation (EC) No. 1830/2003 of the European Parliament and of the Council of 22 September 2003 concerning the traceability and labeling of genetically modified organisms and the traceability of food and feed products produced from genetically modified organisms.

The essential oil of cloves comes from Indonesia, and the essential oil of cinnamon comes from China. All the raw materials are processed in Italy.

After the promising results of the in vitro study, the research is continuing, and currently, a double-blind, placebo-controlled clinical trial is being initiated in patients with recurrent candidiasis in collaboration with various specialists operating in Emilia-Romagna and Liguria centers.

The formulation of Clovedin® is covered by European patent no. WO2023275020.