BIOintestil® is an innovative and natural ingredient, patented and distributed exclusively by Fagron Italy, for the formulation of food supplements for optimal health and wellness of the digestive system.
Its patented formulation is composed of pulverized rhizome of Zingiber officinale Roscoe naturally rich in gingerols on which essential oils are adsorbed titrated in the individual components, such as geraniol, for an anti-inflammatory and antibacterial action, selective against intestinal pathogens, but also with carminative and antiemetic effects.
Geraniol, naturally present in BIOintestil® acts as an inhibitor of cyclooxygenase COX-2 resulting in inhibition of local inflammation mediators and as a natural antidysbiotic action, selectively inhibiting the growth of a broad spectrum of pathogenic bacteria.
Ginger, thanks to the action of 6-gingerol on cyclooxygenase COX-2 and lipoxygenase reduces inflammation and increases intestinal motility, stimulating digestion and simultaneously eliminating constipation and intestinal gas. In addition, the dried ginger rhizome is indicated as an antiemetic.

Optimized and patented formulation
BIointestil® has been formulated with a patented technological process deposited in Europe.
The patent covers:
• the use of essential oils or their individual components adsorbed on vegetable fiber in order to release the active substances of BIOintestil® in the colon.
• The mixing process that optimizes the powder, making it more easily to manipulate and encapsulate.

Clinical study and dosage
On the basis of preclinical scientific studies, and a pilot clinical trial conducted with patients suffering from Irritable Bowel Syndrome (IBS), to be published soon, conducted at the Department of Clinical Medicine, University of Bologna and at the Department of Clinical and experimental Science, Spedali Civili of Brescia, BIOintestil® is able to positively modulate the intestinal microbiota, to reduce bloating and to regularize the bowel. The results of these studies suggest a maximum daily dose of 1800 mg. The effectiveness on the modulation of intestinal microbiota and on the reduction of clinical signs of colitis is observed already after 2 weeks, starting from a dose of 600 mg / day.

BIOintestil® can be used, according to the scientific literature and to the indications from regulatory bodies of European and non-European countries, as a food supplements for intestinal health, as an aid in the digestive process and in restoring proper function and bowel regularity, helping to eliminate swelling, abdominal pain and flatulence. BIOintestil® can be formulated with fibers and / or probiotics.