Beta Caryophyllene: Nature’s Answer to Neuropathic Pain - TGD

Beta Caryophyllene: Nature’s Answer to Neuropathic Pain

Neuropathic pain is a debilitating condition that affects millions worldwide. It arises from damage or dysfunction of the nervous system and results in chronic and often disabling pain sensations. While various treatment options exist, they often come with significant side effects. Hence, research efforts have intensified to find less invasive alternatives for pain relief. In this context, Beta-Caryophyllene emerges as a potent natural remedy with anti-inflammatory and analgesic properties.

What is beta caryophyllene?

It is an aromatic molecule found in various essential oils, including Clove (Syzygium aromaticum), Cannabis (Cannabis sativa) and Copaiba (Copaifera officinalis). Beta caryophyllene is a terpene known for its beneficial effects on human health. These include its ability to modulate neuropathic pain. Beta-caryophyllene acts on a body system called the endocannabinoid system, which is involved in regulating pain, mood, and inflammation. Specifically, it binds to the CB2 receptors of the endocannabinoid system. Here, it plays a key role in

  • reducing inflammatory responses and
  • modulating pain perception.

A significant advantage of beta-caryophyllene is its non-psychoactive nature, unlike other compounds found, for example, in Cannabis. This means it can offer therapeutic benefits without the psychoactive side effects associated. The consultation of a professional before use is essential, in order to exclude individual sensitivities.

Does Beta Caryophyllene have side effects or contraindications?

The contraindications are relatively few. These may include interactions with medications that act on the endocannabinoid system. It is always advisable to consult a doctor before taking it during pregnancy or breastfeeding. Although it’s considered safe for many individuals, some people may experience allergic reactions or interactions with existing medications.


A research group at the University of Siena, in Tuscany (Italy) has discovered a potent synergy between beta-caryophyllene and a particular omega-3 fatty acid, DHA. In fact, in vivo experiments on pain models have shown that these two compounds together can reduce pain perception. TGD has picked up on this work and completed a three-element synergy, that also includes eugenol, another characteristic compound of Clove Essential Oil. In particular, the complex of this essential oil has great antioxidant potential, which can be of great help in cases of inflammation, often present in painful conditions. You can find Clove Essential Oil with high levels of eugenol and beta-caryophyllene along with DHA in Algistat complex, our capsule supplement.

beta caryophyllene algistat


Receive periodic updates on searches for articles of interest

    I consent to receive newsletters as indicated in the information by accepting the terms of the Privacy Policy.