{"id":2293,"date":"2025-02-17T16:08:18","date_gmt":"2025-02-17T15:08:18","guid":{"rendered":"https:\/\/www.tgd.care\/materie_prime\/limenorm\/"},"modified":"2025-05-05T12:35:50","modified_gmt":"2025-05-05T10:35:50","slug":"limenorm","status":"publish","type":"materie_prime","link":"https:\/\/www.tgd.care\/en\/raw_materials\/limenorm\/","title":{"rendered":"Limenorm\u00ae"},"content":{"rendered":"<section class=\"l-section wpb_row height_auto width_full with_shape\"><div class=\"l-section-shape type_wave pos_bottom on_front\" style=\"height:50px;color:#faf4ed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 4 64 4\" preserveAspectRatio=\"none\" width=\"100%\" height=\"100%\">\r\n\t<path fill=\"currentColor\" d=\"M64 6 C32 0 32 12 0 6 L0 8 L64 8 Z\"\/>\r\n<\/svg><\/div><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_3-2 laptops-cols_inherit tablets-cols_1 mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:5.7vw;\"><div class=\"wpb_column vc_column_container us_custom_cfdd3aa0\"><div class=\"vc_column-inner\"><div class=\"w-separator size_large\"><\/div><div class=\"w-image us_custom_3000a3fb has_ratio align_none\"><div class=\"w-image-h\"><div style=\"padding-bottom:42.8571%\"><\/div><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2024\/12\/1.svg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" \/><\/div><\/div><div class=\"w-separator size_custom\" style=\"height:8px\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>The natural balance for your metabolism.<\/strong><\/p>\n<ul>\n<li>Innovative solution for managing energy metabolism imbalances<\/li>\n<li>Modulation of the gut microbiota<\/li>\n<li>Clinically Tested<\/li>\n<li>Patent pending<\/li>\n<\/ul>\n<p>Limenorm\u00ae, an innovative formulation based on sweet orange essential oil and cocoa fiber, is an innovative ingredient for improving energy metabolism and modulating the gut microbiota.<\/p>\n<\/div><\/div><div class=\"w-separator size_medium\"><\/div><div class=\"w-tabs style_default switch_click accordion has_scrolling\" style=\"--sections-title-size:inherit\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section\" id=\"h771\"><button class=\"w-tabs-section-header\" aria-controls=\"content-h771\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Benefits<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-h771\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Limenorm\u00ae is an innovative and completely natural ingredient for dietary supplements with eubiotic activity, created with a patent pending formulation based on sweet orange essential oil (Citrus aurantium var. dulcis), adsorbed onto cocoa fiber (Theobroma cacao). Based on preclinical scientific studies, Limenorm\u00ae has been shown to reduce hunger, positively modulate the gut microbiota, and improve fasting blood glucose levels. A clinical trial is currently underway with patients suffering from Metabolic Syndrome, conducted at the Department of Medical and Surgical Sciences of the University of Bologna, in Italy.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"a8ef\"><button class=\"w-tabs-section-header\" aria-controls=\"content-a8ef\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Applications<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-a8ef\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Limenorm\u00ae is indicated for the formulation of supplements and foods to support alterations in energy metabolism. You can find it in Liporange Complex, <a href=\"https:\/\/www.tgd.care\/en\/liporange-complex\/\">learn more<\/a>.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"ga61\"><button class=\"w-tabs-section-header\" aria-controls=\"content-ga61\" aria-expanded=\"false\"><div class=\"w-tabs-section-title\">Mechanism of Action<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-ga61\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>In the innovative formulation of Limenorm\u00ae, the sweet orange oil adsorbed onto cocoa fiber powder is able to pass intact through the stomach and the first part of the intestine. The bioavailability of D-Limonene, the main component of sweet orange essential oil, in this formulation is reduced to zero, as confirmed by our pharmacokinetic studies. The digestion of cocoa fiber by the gut microbiota exerts a prebiotic effect and allows the release of the essential oil directly into the colon, where it can exert its antimicrobial effect, improving the composition of the gut microbiota and promoting the improvement of alterations in energy metabolism.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-slider us_custom_0ccc3812 style_none fit_cover nav_none has_ratio count_3\" style=\"--aspect-ratio: 3\/4;\"><div class=\"w-slider-h\"><div class=\"royalSlider\"><div class=\"rsContent\"><a class=\"rsImg\" data-rsw=\"855\" data-rsh=\"775\" href=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2024\/12\/Limenorm-1.jpg\"><span data-alt=\"\"><\/span><\/a><\/div><div class=\"rsContent\"><a class=\"rsImg\" data-rsw=\"855\" data-rsh=\"775\" href=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2024\/12\/a-metabolismo-energetico-limenorm.jpg\"><span data-alt=\"\"><\/span><\/a><\/div><div class=\"rsContent\"><a class=\"rsImg\" data-rsw=\"855\" data-rsh=\"775\" href=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2024\/12\/fibra-di-cacao.jpg\"><span data-alt=\"\"><\/span><\/a><\/div><\/div><img decoding=\"async\" src=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2024\/12\/Limenorm-1.jpg\" width=\"855\" height=\"775\" alt loading=\"lazy\"><\/div><div class=\"w-slider-json\" onclick='return {&quot;autoScaleSlider&quot;:false,&quot;addActiveClass&quot;:true,&quot;loop&quot;:true,&quot;fadeInLoadedSlide&quot;:false,&quot;slidesSpacing&quot;:0,&quot;imageScalePadding&quot;:0,&quot;numImagesToPreload&quot;:2,&quot;arrowsNav&quot;:false,&quot;arrowsNavAutoHide&quot;:false,&quot;transitionType&quot;:&quot;fade&quot;,&quot;transitionSpeed&quot;:1300,&quot;block&quot;:{&quot;moveEffect&quot;:&quot;none&quot;,&quot;speed&quot;:300},&quot;thumbs&quot;:{&quot;fitInViewport&quot;:false,&quot;firstMargin&quot;:false,&quot;spacing&quot;:4},&quot;controlNavigation&quot;:&quot;none&quot;,&quot;autoplay&quot;:{&quot;enabled&quot;:true,&quot;pauseOnHover&quot;:false,&quot;delay&quot;:4000}}'><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_huge with_shape\"><div class=\"l-section-overlay\" style=\"background:#faf4ed\"><\/div><div class=\"l-section-shape type_wave pos_bottom\" style=\"height:50px;\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 4 64 4\" preserveAspectRatio=\"none\" width=\"100%\" height=\"100%\">\r\n\t<path fill=\"currentColor\" d=\"M64 6 C32 0 32 12 0 6 L0 8 L64 8 Z\"\/>\r\n<\/svg><\/div><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_2-1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_middle type_default stacking_default\" style=\"--gap:5.1rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-video us_custom_7cb69c13 align_none ratio_16x9 has_border_radius has_iframe\"><div class=\"w-video-h\"><iframe title=\"Youtube video player\" src=\"\/\/www.youtube.com\/embed\/WAl88OlitYE?autoplay=0&controls=0&origin=https:\/\/www.tgd.care\/en\/&loop=0&mute=0\" allowfullscreen=\"1\" loading=\"lazy\"><\/iframe><\/div><div class=\"w-video-icon\" style=\"font-size:1.5rem;background:rgba(0,0,0,0.5);color:#fff\"><\/div><\/div><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-actionbox us_custom_6aa9e45b has_text_color color_light controls_bottom\"><div class=\"w-actionbox-text\"><h2 class=\"w-actionbox-title\">Interested? <\/h2><\/div><div class=\"w-actionbox-controls\"><a class=\"w-btn us-btn-style_1\" href=\"\/en\/contacts\/\"><span class=\"w-btn-label\">Contact us <\/span><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_c70c97eb height_large\"><div class=\"l-section-overlay\" style=\"background:var(--color-header-middle-bg)\"><\/div><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h5>Do you have questions?<br \/>\nWe have the answers<\/h5>\n<\/div><\/div><div class=\"w-separator size_medium\"><\/div><div class=\"w-tabs style_default switch_click accordion type_togglable has_scrolling remove_indents\" style=\"--sections-title-size:1.2rem\"><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section has_text_color\" id=\"cc4c\" style=\"color:var(--color-header-middle-text);\"><button class=\"w-tabs-section-header\" aria-controls=\"content-cc4c\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">What is Limenorm\u00ae used for?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-cc4c\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>Limenorm\u00ae is an innovative raw material for completely plant-based dietary supplements. It can be used alone or in combination with other ingredients to formulate supplements that support energy metabolism and digestive functions.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"odf2\"><button class=\"w-tabs-section-header\" aria-controls=\"content-odf2\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">What influence does the intestinal microbiota have on energy metabolism?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-odf2\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d1 active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>In the majority of individuals, obesity is the result of modern lifestyle, which exposes each of us to an environment defined as &#8216;obesogenic,&#8217; leading us to eat more, modify the quality of food, and engage in less physical activity. The intestinal microbiota also appears to play a significant role in the pathophysiology of obesity. Numerous studies show a link between intestinal dysbiosis and metabolic syndrome, due to the microbiota&#8217;s ability to modulate the host&#8217;s energy metabolism through the production of short-chain fatty acids from the fermentation and hydrolysis of polysaccharides (mainly fiber). These fatty acids can influence intestinal transit and the host&#8217;s sensation of satiety. The Western diet, characterized by high consumption of refined flours, red meat, saturated fats, sugars, processed foods, and insufficient fiber intake, significantly contributes to intestinal dysbiosis and a low-grade systemic inflammation, which are considered key elements in the development and maintenance of metabolic syndrome.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"ef81\"><button class=\"w-tabs-section-header\" aria-controls=\"content-ef81\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Why are Sweet Orange Essential Oil and Cocoa Fiber present?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-ef81\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d2 active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>Orange Essential Oil contributes to maintaining digestive function and eliminating intestinal gas. Some components of essential oils have a eubiotic action, which means selective antimicrobial, with beneficial effects on the balance of the intestinal microbiota. Cocoa supports metabolic activity and normal mood tone and contains flavanols, polyphenols with antioxidant properties.<\/p>\n<\/div>\n<\/div>\n<div class=\"toggle rel-p with-effect-d3 active-effect\">\n<div class=\"toggle-title bg-sz med no-mg\"><\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"c10b\"><button class=\"w-tabs-section-header\" aria-controls=\"content-c10b\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Why is Limenorm\u00ae an innovative product?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-c10b\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d3 active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>The innovative formulation of Limenorm\u00ae is based on the use of a patent pending preparation of sweet orange essential oil adsorbed onto cocoa fiber. According to pharmacokinetic studies, this particular formulation allows it to pass through the first part of the intestine intact and reach the colon where, following the degradation of the fiber by the intestinal microbiota, the oil is released in high percentage and promotes the natural rebalancing of the microbial community.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"j288\"><button class=\"w-tabs-section-header\" aria-controls=\"content-j288\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Is Limenorm\u00ae a safe ingredient?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-j288\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Preliminary studies conducted on an experimental murine model and in humans have demonstrated that the components of Limenorm\u00ae are safe.<br \/>\nCocoa powder is widely used in the food industry and has never shown toxicity at the recommended dosages in the supplement. Sweet Orange Essential Oil is classified as GRAS by the FDA and is included in the list of botanicals permitted in dietary supplements (Annex 1, Ministerial Decree 10\/08\/2018, Italian Ministry of Health).<br \/>\nAs specific studies are not available, it is advisable to avoid the consumption of Limenorm\u00ae-based products during pregnancy, breastfeeding, and in pediatric age as a precaution. Its use is also not recommended in cases of renal or hepatic insufficiency, as the metabolism of essential oils and their derivatives primarily involves the liver and kidneys.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"b424\"><button class=\"w-tabs-section-header\" aria-controls=\"content-b424\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Is there a regulatory framework that covers the ingredients of Limenorm\u00ae?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-b424\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>There is a comprehensive European regulatory framework that covers the safe use of the product&#8217;s ingredients:<br \/>\nThe Essential Oil of Citrus aurantium var. dulcis Hayne and the powder of Theobroma cacao L. seed are certified for food use.<br \/>\nAccording to DM 27\/03\/2014 of the Ministry of Health, the use of Citrus aurantium var. dulcis Hayne essential oil is approved in food supplements for digestive function and elimination of intestinal gas.<br \/>\nAccording to DM 27\/03\/2014 of the Ministry of Health, the use of Theobroma cacao L. seed is approved in antioxidant food supplements for metabolic support and maintenance of normal mood.<br \/>\nAccording to Regulation (EC) 1924\/2006 of the European Parliament and of the Council of 20 December 2006 on nutrition and health claims made on foods, Limenorm\u00ae can be defined as a &#8220;source of fiber.&#8221;<br \/>\nAccording to Regulation (EC) No. 1907\/2006 of the European Parliament and of the Council of 18 December 2006 concerning the registration, evaluation, authorization, and restriction of chemicals (REACH), which establishes a European Chemicals Agency, Limenorm\u00ae is composed 100% of a mixture of ingredients that meets the definition of &#8220;substances occurring in nature.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"q5bc\"><button class=\"w-tabs-section-header\" aria-controls=\"content-q5bc\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Has Limenorm\u00ae been clinically tested?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-q5bc\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>Limenorm\u00ae has been developed by TGD s.r.l., a spin-off of the University of Bologna, which has tested the formulation in preclinical studies (Valerii et al., 2021) and on human microbiota and microbiome (Nissen et al., 2021).<br \/>\nPreclinical scientific studies were conducted on an animal model of obesity induced by a high-fat diet and demonstrated the effectiveness of Limenorm\u00ae in positively modulating the gut microbiota, reducing the presence of specific bacterial strains that negatively impact blood triglyceride and glucose levels. The results on human microbiota and microbiome also revealed that the action of Limenorm\u00ae is capable of rebalancing microbial metabolism.<br \/>\nA randomized, double-blind clinical trial on patients with Metabolic Syndrome is currently underway at the S. Orsola-Malpighi Hospital, University of Bologna.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"o758\"><button class=\"w-tabs-section-header\" aria-controls=\"content-o758\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Is Limenorm\u00ae GMO-free?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-o758\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d active-effect\">\n<div class=\"toggle-inner post-content\">\n<div class=\"toggle rel-p with-effect-d2 active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>Limenorm\u00ae is GMO-free. It does not contain, derive from, or consist of Genetically Modified Organisms. Limenorm\u00ae is compliant with Regulations EC No. 1829\/2003 and No. 1830\/2003.<br \/>\nIn particular:<\/p>\n<p>Regulation (EC) No. 1829\/2003 of the European Parliament and of the Council, dated 22 September 2003, on genetically modified food and feed;<br \/>\nRegulation (EC) No. 1830\/2003 of the European Parliament and of the Council, dated 22 September 2003, concerning the traceability and labeling of genetically modified organisms and the traceability of food and feed products produced from genetically modified organisms.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"t8f8\"><button class=\"w-tabs-section-header\" aria-controls=\"content-t8f8\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">Where do the ingredients of Limenorm\u00ae come from?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-t8f8\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d active-effect\">\n<div class=\"toggle-inner post-content\">\n<div class=\"toggle rel-p with-effect-d2 active-effect\">\n<div class=\"toggle-inner post-content\">\n<div class=\"toggle rel-p with-effect-d3 active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>The raw materials of Limenorm\u00ae are sourced from Africa\/South America (Cocoa) and Europe (Orange Essential Oil), their native environments, while their processing takes place in Italy.<br \/>\nThe quality of the raw materials is checked twice: upon arrival in Italy, the analysis certifications are reviewed again by distributors and producers to verify the active ingredient content and the presence of pesticides, mycotoxins, allergens, and microbial load.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"pa90\"><button class=\"w-tabs-section-header\" aria-controls=\"content-pa90\" aria-expanded=\"false\"><h6 class=\"w-tabs-section-title\">How is Limenorm\u00ae produced?<\/h6><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-pa90\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"toggle rel-p with-effect-d active-effect\">\n<div class=\"toggle-inner post-content\">\n<div class=\"toggle rel-p with-effect-d2 active-effect\">\n<div class=\"toggle-inner post-content\">\n<div class=\"toggle rel-p with-effect-d3 active-effect\">\n<div class=\"toggle-inner post-content\">\n<p>The cocoa seeds are dried and processed into powder in Italy.<br \/>\nThe Sweet Orange Essential Oil is added to the mixture and absorbed into the powder in Italy.<br \/>\nThis is how Limenorm\u00ae powder is obtained.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-separator size_medium\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small color_alternate\"><div class=\"l-section-overlay\" style=\"background:var(--color-content-bg-alt)\"><\/div><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_3-1 laptops-cols_2-1 tablets-cols_inherit mobiles-cols_1 valign_middle type_default\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><h5 class=\"w-text\"><span class=\"w-text-h\"><span class=\"w-text-value\">Discover the related supplement<\/span><\/span><\/h5><\/div><\/div><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"w-btn-wrapper default_align_right laptops_align_right tablets_align_right mobiles_align_none\"><a class=\"w-btn us-btn-style_1 icon_atleft text_none\" aria-label=\"Button\" href=\"\/en\/liporange-complex\/\"><i class=\"fas fa-arrow-right\"><\/i><\/a><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_huge\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_grid cols_1 laptops-cols_inherit tablets-cols_inherit mobiles-cols_1 valign_top type_default stacking_default\" style=\"--gap:2.8rem;\"><div class=\"wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h5 class=\"info-title\" style=\"text-align: left;\">Articles about it<\/h5>\n<\/div><\/div><div class=\"w-separator us_custom_a5c0e80c size_custom with_line width_default thick_3 style_solid color_primary align_center\" style=\"height:1\"><div class=\"w-separator-h\"><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-grid type_grid layout_564 cols_4 valign_center overflow_hidden\" id=\"us_grid_1\" style=\"--gap:1rem;\" data-filterable=\"true\"><style>@media (max-width:1380px){#us_grid_1 .w-grid-item{width:33.3333%}}@media (max-width:1024px){#us_grid_1 .w-grid-item{width:50%}}@media (max-width:899px){#us_grid_1 .w-grid-list{margin:0}#us_grid_1 .w-grid-item{width:100%;padding:0;margin-bottom:var(--gap,0px)}}@media (min-width:1024px){#us_grid_1 .w-post-elm.post_title{font-size:16px!important}}.layout_564 .w-grid-item-h{background:#333;border-radius:0.3rem;box-shadow:0 0.12rem 0.24rem rgba(0,0,0,0.1),0 0.4rem 1.2rem rgba(0,0,0,0.1);transition-duration:0.3s}.no-touch .layout_564 .w-grid-item-h:hover{box-shadow:0 0.2rem 0.4rem rgba(0,0,0,0.1),0 0.67rem 2rem rgba(0,0,0,0.15);z-index:4}.layout_564 .usg_post_image_1{transition-duration:0.3s;transform-origin:50% 50%;transform:scale(1) translate(0%,0%)}.layout_564 .w-grid-item-h:hover .usg_post_image_1{transform:scale(1.1) translate(0%,0%);opacity:1}.layout_564 .usg_vwrapper_1{position:absolute!important;left:0!important;bottom:0!important;right:0!important;background:linear-gradient(transparent,rgba(30,30,30,0.9))!important;padding:15% 7% 5% 7%!important}.layout_564 .usg_post_title_1{color:#fff!important;font-size:1.4rem!important;font-weight:700!important}@media (max-width:600px){.layout_564 .usg_post_title_1{font-size:1.2rem!important}}<\/style><div class=\"w-grid-list\">\t<article class=\"w-grid-item post-3347 post type-post status-publish format-standard has-post-thumbnail hentry category-digestion category-energy-metabolism category-immune-system category-nervous-system category-womens-health\" data-id=\"3347\">\r\n\t\t<div class=\"w-grid-item-h\">\r\n\t\t\t\t\t\t<div class=\"w-post-elm post_image usg_post_image_1 stretched\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/digestion\/bioavailability\/\" aria-label=\"Bioavailability: When Less is More\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"853\" src=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2026\/03\/biodisponibilita-0326-1024x853.png\" class=\"attachment-large size-large wp-post-image\" alt=\"biodisponibilit\u00e0\" srcset=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2026\/03\/biodisponibilita-0326-1024x853.png 1024w, https:\/\/www.tgd.care\/wp-content\/uploads\/2026\/03\/biodisponibilita-0326-300x250.png 300w, https:\/\/www.tgd.care\/wp-content\/uploads\/2026\/03\/biodisponibilita-0326-480x400.png 480w, https:\/\/www.tgd.care\/wp-content\/uploads\/2026\/03\/biodisponibilita-0326-900x750.png 900w, https:\/\/www.tgd.care\/wp-content\/uploads\/2026\/03\/biodisponibilita-0326-600x500.png 600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/div><div class=\"w-vwrapper usg_vwrapper_1 align_none valign_top\"><h2 class=\"w-post-elm post_title usg_post_title_1 has_text_color entry-title color_link_inherit\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/digestion\/bioavailability\/\">Bioavailability: When Less is More<\/a><\/h2><\/div>\t\t<\/div>\r\n\t\t\t<\/article>\r\n\t<article class=\"w-grid-item post-3304 post type-post status-publish format-standard has-post-thumbnail hentry category-articles category-digestion\" data-id=\"3304\">\r\n\t\t<div class=\"w-grid-item-h\">\r\n\t\t\t\t\t\t<div class=\"w-post-elm post_image usg_post_image_1 stretched\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/microbiota-gut-brain-axis\/\" aria-label=\"The Microbiota\u2013Gut\u2013Brain Axis: The Complete Updated Overview\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"500\" src=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/01\/asse-microbiota-intestino-cervello-copertina.jpg\" class=\"attachment-large size-large wp-post-image\" alt=\"\" srcset=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/01\/asse-microbiota-intestino-cervello-copertina.jpg 600w, https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/01\/asse-microbiota-intestino-cervello-copertina-300x250.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/div><div class=\"w-vwrapper usg_vwrapper_1 align_none valign_top\"><h2 class=\"w-post-elm post_title usg_post_title_1 has_text_color entry-title color_link_inherit\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/microbiota-gut-brain-axis\/\">The Microbiota\u2013Gut\u2013Brain Axis: The Complete Updated Overview<\/a><\/h2><\/div>\t\t<\/div>\r\n\t\t\t<\/article>\r\n\t<article class=\"w-grid-item post-3189 post type-post status-publish format-standard has-post-thumbnail hentry category-articles category-digestion category-energy-metabolism category-immune-system category-nervous-system category-womens-health\" data-id=\"3189\">\r\n\t\t<div class=\"w-grid-item-h\">\r\n\t\t\t\t\t\t<div class=\"w-post-elm post_image usg_post_image_1 stretched\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/essential-oils\/\" aria-label=\"Essential Oils: What They Are, Benefits and Their Role in Health\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"500\" src=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2023\/05\/oli-essenziali-copertina-2025.png\" class=\"attachment-large size-large wp-post-image\" alt=\"oli essenziali copertina 2025\" srcset=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2023\/05\/oli-essenziali-copertina-2025.png 600w, https:\/\/www.tgd.care\/wp-content\/uploads\/2023\/05\/oli-essenziali-copertina-2025-300x250.png 300w, https:\/\/www.tgd.care\/wp-content\/uploads\/2023\/05\/oli-essenziali-copertina-2025-480x400.png 480w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/div><div class=\"w-vwrapper usg_vwrapper_1 align_none valign_top\"><h2 class=\"w-post-elm post_title usg_post_title_1 has_text_color entry-title color_link_inherit\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/essential-oils\/\">Essential Oils: What They Are, Benefits and Their Role in Health<\/a><\/h2><\/div>\t\t<\/div>\r\n\t\t\t<\/article>\r\n\t<article class=\"w-grid-item post-3053 post type-post status-publish format-standard has-post-thumbnail hentry category-digestion\" data-id=\"3053\">\r\n\t\t<div class=\"w-grid-item-h\">\r\n\t\t\t\t\t\t<div class=\"w-post-elm post_image usg_post_image_1 stretched\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/digestion\/biointestil-real-life-study-2025\/\" aria-label=\"Real-Life Study: Effectiveness of BIOintestil\u00ae in the Management of IBS\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"853\" src=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625-1024x853.png\" class=\"attachment-large size-large wp-post-image\" alt=\"real life study BIOintestil IBS 2025\" srcset=\"https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625-1024x853.png 1024w, https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625-300x250.png 300w, https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625-480x400.png 480w, https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625-900x750.png 900w, https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625-600x500.png 600w, https:\/\/www.tgd.care\/wp-content\/uploads\/2025\/06\/Copertina-articolo-real-life-study-0625.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/div><div class=\"w-vwrapper usg_vwrapper_1 align_none valign_top\"><h2 class=\"w-post-elm post_title usg_post_title_1 has_text_color entry-title color_link_inherit\"><a href=\"https:\/\/www.tgd.care\/en\/articles\/digestion\/biointestil-real-life-study-2025\/\">Real-Life Study: Effectiveness of BIOintestil\u00ae in the Management of IBS<\/a><\/h2><\/div>\t\t<\/div>\r\n\t\t\t<\/article>\r\n<\/div><div class=\"w-grid-preloader\">\t<div class=\"g-preloader type_1\">\r\n\t\t<div><\/div>\r\n\t<\/div>\r\n\t<\/div>\t<div class=\"w-grid-json hidden\" onclick='return {&quot;action&quot;:&quot;us_ajax_grid&quot;,&quot;infinite_scroll&quot;:0,&quot;max_num_pages&quot;:3,&quot;pagination&quot;:&quot;none&quot;,&quot;template_vars&quot;:{&quot;columns&quot;:&quot;4&quot;,&quot;exclude_items&quot;:&quot;none&quot;,&quot;img_size&quot;:&quot;default&quot;,&quot;ignore_items_size&quot;:&quot;1&quot;,&quot;items_layout&quot;:&quot;564&quot;,&quot;items_offset&quot;:&quot;1&quot;,&quot;load_animation&quot;:&quot;none&quot;,&quot;overriding_link&quot;:&quot;{\\&quot;url\\&quot;:\\&quot;\\&quot;}&quot;,&quot;post_id&quot;:0,&quot;query_args&quot;:{&quot;post_type&quot;:[&quot;post&quot;],&quot;tax_query&quot;:[{&quot;taxonomy&quot;:&quot;category&quot;,&quot;field&quot;:&quot;slug&quot;,&quot;terms&quot;:[&quot;digestione&quot;]}],&quot;post_status&quot;:[&quot;publish&quot;,&quot;acf-disabled&quot;],&quot;posts_per_page&quot;:&quot;4&quot;},&quot;orderby_query_args&quot;:{&quot;orderby&quot;:{&quot;date&quot;:&quot;DESC&quot;}},&quot;type&quot;:&quot;grid&quot;,&quot;us_grid_post_type&quot;:&quot;post&quot;,&quot;us_grid_ajax_index&quot;:1,&quot;us_grid_filter_query_string&quot;:null,&quot;us_grid_index&quot;:1,&quot;page_args&quot;:[],&quot;lang&quot;:&quot;en&quot;}}'><\/div>\r\n\t<\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"To evaluate the effectiveness of BIOintestil\u00ae, a real-life, open-label study was conducted in collaboration with Italian gastroenterologists on patients experiencing symptoms consistent with Irritable Bowel Syndrome (IBS). IBS is currently the most common functional gastrointestinal disorder. It is a chronic and relapsing condition that, in the absence of identifiable organic causes, is diagnosed based on...","protected":false},"featured_media":890,"menu_order":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"materie_prime":[],"class_list":["post-2293","materie_prime","type-materie_prime","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>TGD | Ricerca e Sviluppo di Integratori Alimentari<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:site_name\" content=\"TGD | Ricerca e Sviluppo di Integratori Alimentari\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"CollectionPage\",\"@id\":null,\"url\":\"\",\"name\":\"\",\"isPartOf\":{\"@id\":\"https:\/\/www.tgd.care\/#website\"},\"inLanguage\":\"en-US\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.tgd.care\/#website\",\"url\":\"https:\/\/www.tgd.care\/\",\"name\":\"TGD | Ricerca e Sviluppo di Integratori Alimentari\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.tgd.care\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"TGD | Ricerca e Sviluppo di Integratori Alimentari","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_site_name":"TGD | Ricerca e Sviluppo di Integratori Alimentari","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"CollectionPage","@id":null,"url":"","name":"","isPartOf":{"@id":"https:\/\/www.tgd.care\/#website"},"inLanguage":"en-US"},{"@type":"WebSite","@id":"https:\/\/www.tgd.care\/#website","url":"https:\/\/www.tgd.care\/","name":"TGD | Ricerca e Sviluppo di Integratori Alimentari","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.tgd.care\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/materie_prime\/2293"}],"collection":[{"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/materie_prime"}],"about":[{"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/types\/materie_prime"}],"version-history":[{"count":3,"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/materie_prime\/2293\/revisions"}],"predecessor-version":[{"id":3002,"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/materie_prime\/2293\/revisions\/3002"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/media\/890"}],"wp:attachment":[{"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/media?parent=2293"}],"wp:term":[{"taxonomy":"materie_prime","embeddable":true,"href":"https:\/\/www.tgd.care\/en\/wp-json\/wp\/v2\/materie_prime?post=2293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}